All publications
Investigation of the permeation enhancer strategy on benzoylaconitine transdermal patch: the relationship between transdermal enhancement strength and physicochemical properties of permeation enhancer
Eur J Pharm Sci. 2019 Oct 1;138:105009. doi: 10.1016/j.ejps.2019.105009. Epub 2019 Jul 12. - Jul 2019
In this study several permeation enhancers are evaluated for their ability to permeate high molecular weight benzoylaconitine. The results showed that Plurol® Oleique CC 497 enabled the highest permeation. FT-IR studies demonstrated that the enhancer had strong interactions with the Stratum corneum, both in the hydrophilic and lipophilic regions. The optimized patch formulation showed excellent analgesic and antiinflammatory effect.
In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract
International Journal of Pharmaceutics, Volume 565, Pages 409-418 - Jun 2019
Investigation of Labrasol® ALF as an intestinal permeation enhancer: Ussing chambers and intestinal instillations
Poster presented at Keystone Symposia on Molecular and Cellular Biology – Delivering Therapeutics Across Biological Barriers (E1) - Dublin (Ireland) - May 2019
A Proof of Concept for 3D Printing of Solid Lipid-Based Formulations of Poorly Water-Soluble Drugs to Control Formulation Dispersion Kinetics
Pharmaceutical Research volume 36, Article number: 102 doi: 10.1007/s11095-019-2639-y. - May 2019
In this study, the authors show that solid SMEDDS can be produced with a 3D printing process and solid and semi-solid lipid excipients. The proof of concept is established with cinnarizine and fenofibrate as model drugs.
Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs
Advanced Drug Delivery Reviews, Volume 142, Pages 16-34 https://doi.org/10.1016/j.addr.2019.01.008 - May 2019
In this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.
A review of the techniques used to characterize the colloidal structures is also carried out.
An efficient method to determine the Hydrophile-Lipophile Balance of surfactants using the phase inversion temperature deviation of Ci Ej /n-octane/water emulsions.
International Journal of Cosmetic Science, 41, 99–108 doi: 10.1111/ics.12516 - Apr 2019
Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis
International Journal of Pharmaceutics, Volume 559, Pages 228-234 - Mar 2019
Lipids and polymers in pharmaceutical technology: Lifelong companions
International Journal of Pharmaceutics, Volume 558, 10 March 2019, Pages 128-142 - Mar 2019
This article reviews the uses of lipids and polymers in pharmaceutical applications, alone or in combination, with a main focus on oral administration.
These topics were discussed at the Journées galéniques de Saint-Rémy de Provence in 2018, the Scientific Meeting sponsored by Gattefossé Foundation
High shear blending with glyceryl distearate provides individually coated drug particles for effective taste masking
Journal of Drug Delivery Science and Technology, Volume 48, Pages 437-449 - Dec 2018
In this study the authors used:
– A design of experiment, to evaluate the effect of process parameters (blending speed, chopper speed and coating time) on drug particle size.
– Potassium chloride as model drug.
The study showed:
– Individual particle coating was achieved at 450 rpm with 20% glyceryl distearate (Precirol® ATO 5) at 48°C
– High shear coating is as efficient as fluid bed coating for taste masking
– A trained sensory panel confirmed the effectiveness of the process on taste masking