All publications
Development and optimization of a patient-friendly lidocaine nanoemulgel for enhanced skin permeation
AAPS - Oct 2026
In this study, we developed and characterized a lidocaine nanoemulgel with enhanced topical delivery performance. Nanoemulgels combine the advantages of nanoemulsions, including improved drug solubilization and skin permeation, with the favorable properties of hydrogels, such as improved skin retention, ease of application, and patient acceptability. Three excipients—Labrasol® ALF, Capryol® 90, and Transcutol® P were selected to develop nanoemulgels given their emulsifying, solubilizing, and permeation-enhancing properties.
Tablet lipid-based drug delivery through adsorption process: development and use of a stepwise methodology
AAPS - Oct 2026
The study aimed to develop a methodology for selecting inert carriers to adsorb lipid-based formulations (LBFs), thereby optimizing the oral bioavailability of BCS Class II/IV APIs in tablets. Integrating a lipid matrix consisting of Labrasol ® ALF and Labrafac™ MC60 successfully modulated the release kinetics of ticagrelor, proving to be a highly effective strategy for optimized drug availability.
TIM-1 as a biorelevant dynamic in vitro tool to screen lipid-based formulations
AAPS - Oct 2026
TIM-1, a gastro-intestinal model, is a powerful and highly biorelevant in vitro tool, closely mimicking human gastro-intestinal physiology by integrating transit, motility, pH changes, bile salt and enzyme secretions. This model enabled detailed evaluation of lipid-based formulations under dynamic conditions, providing insights that go beyond standard in vitro tests.
In-line incorporation of Labrasol® as a permeation enhancer in ASDs by continuous hot melt extrusion: process development and optimization
American DDF Summit 2026 - Sep 2026
This poster explores the in-line incorporation of Labrasol® into amorphous solid dispersions (ASDs) using continuous hot melt extrusion. Using fenofibrate as a model poorly water-soluble drug, the study demonstrates a scalable approach for combining lipid excipients with ASDs while maintaining processability, stability, and dissolution performance.
Ear cleanser and fluid bi-gel as complementary formulations of an otic care platform for pets
ABCF - Oct 2026
This study shows how to develop and preliminarily characterize an emulsifying ear cleanser and a drug-loaded fluidbi-gel as complementary formulations for veterinary otic care.
Poster CRS Lyon 2026 - The role of in vitro model complexity in lipid-based formulations screening a case study with ticagrelor
CRS Lyon 2026 - Oct 2026
This poster evaluates different in vitro tools, ranging from simple to highly complex models (dissolution, lipolysis, and TIM), to characterize lipid-based formulations. The results show that each model captures different biopharmaceutical phenomena depending on its level of complexity, meaning that no single tool provides a complete picture.
Improving the Drug Loading Capacity and Downstream Processing of HPMCAS using Gelucire® 48/16 in Hot-Melt Extrusion
CRS Annual Meeting 2026 - Jul 2026
This poster demonstrates how Gelucire® 48/16 enhances the hot-melt extrusion process, improves tabletability, and increases drug loading and release from HPMCAS-based amorphous solid dispersions.
Transcutol® V, a must-have, safe and versatile excipient for optimised veterinary medicines
International Animal Health Journal - Jul 2026
In this whitepaper, we focus on Transcutol® V, a powerful solvent, solubiliser and penetration enhancer, largely used across major animal species and in a variety of dosage forms. The main properties of Transcutol® V are described in comparison to other solvents used in veterinary medicines worldwide. Applications in oral, skin and injectable drug delivery are illustrated through market references and case studies elaborated in our Technical Centres of Excellence.
Strategic Excipient Sourcing: Navigating Supply Chain Resilience, Quality & Sustainability by Design
Drug Development & Delivery - May 2026
This article explores key considerations for selecting an excipient supplier, including supply chain resilience, quality/regulatory support, and environmental sustainability. Learn how Gattefossé is enabling next-generation therapies with localized manufacturing and sustainable, lipid-based solutions.