All publications
Process analytical strategies for size monitoring: offline, at-line, online, and inline methods in a top-down nano-manufacturing line
Pharmaceutics - May 2025
This study highlights that combining offline, at-line, in-line, and online DLS methods enables thorough monitoring across the entire lipid nanoparticles production process. This integrated approach streamlines operations, supports real-time process adjustments, and ensures dependable quality control both post-production and during storage.
In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations
ECP - Mar 2025
In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.
A QbD-based UPLC-ELSD method for quantifying medium-chain triglycerides in Labrafac™ WL 1349 for nanoemulsion applications
Molecules - Jan 2025
This article showcases the development and validation of a robust UPLC-ELSD method, using analytical Quality-by-Design principles, to accurately quantify medium-chain triglycerides in a lipid-based excipient for nanoemulsion applications, ensuring compliance with regulatory standards.
Understanding Microemulsions and Nanoemulsions in (Trans)Dermal Delivery
AAPS PharmSciTech - Jan 2025
Microemulsions and nanoemulsions are explored in pharmaceuticals for their potential in delivering clinically relevant drug doses across biological membranes. Despite extensive literature, there's a lack of clear distinctions between the two in terms of definitions and mechanisms: this review aims to uncover less obvious yet important mechanisms in transdermal drug delivery.
Bigels: case studies of an innovative topical dosage form
ABCF Congress - Nov 2024
Adherence to treatments is a key challenge for topical formulations. Bigels, formulated with Emulfree® Duo are an innovative dosage form that can combine both hydrophilic and lipophilic active ingredients in a stable, moisturizing, and easily spreadable formulation. This study showcases three different placebo bigels formulations.
Precision Engineering of Lipid-Based Nanosystems via Impingement Jet Mixing
PBP - Mar 2024
Formulation Components' Role in Shaping Continuous Nanocarrier Production through Impingement Jet Mixing
PBP - Mar 2024
Flash nanoemulsification with impingement jet mixing is a technique used to produce nanocarriers. This study optimized the nanocarrier formulation to facilitate the manufacturing process and monitoring.
Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line considering critical measurement and process conditions
PBP - Mar 2024
Nanopharmaceuticals' size is a critical quality attribute. This work provides insights about the implementation of an at-line particle size analyzer in a continuous manufacturing line of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC).
Formulating pharmaceutical topical dosage forms with high level of solvents and minimal quantity of water
PBP - Mar 2024
This poster dives into the formulation of topical dosage forms containing the maximum amount of solvent and the minimum amount of water, while ensuring their stability upon storage.