All publications

Advantages of combining polymers and lipids in extrusion processes

  • Poster

PBP - Mar 2024

Ceren Yüce, Lolie Cheron, Anja Geissler-Fichtner, Elsa Gattefossé

Lipid excipients lower the glass transition temperature of polymers, enabling hot-melt extrusion at lower engine torque for better processability. Different polymers and lipid combinations have been tested to explore their potential in extrusion processes.

Compritol® 888 ATO vs Precirol® ATO 5 in hot melt extrusion: investigation of operating window limits

  • Poster

AAPS Annual Meeting and Exposition – San Diego (USA)  - Nov 2014

Yvonne Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane, Delphine Marchaud

Is Compritol® 888 ATO chemically stable in hot melt extrusion process at high temperature?

  • Poster

AAPS Annual Meeting and Exposition – San Diego (USA)  - Nov 2014

Yvonne Rosiaux, Jean-Michel Girard, Florence Desvignes, Cédric Miolane, Delphine Marchaud

Solid lipid excipients: born to be extruded!

  • Whitepaper

Nov 2014

Gattefossé

Functional excipients are critical to the successful application of HME to resolve formulation challenges. Whilst polymers show potential in both controlled release and in improving the solubility and dissolution of poorly soluble compounds they are not ideal materials for extrusion. Lipid excipients are distinctly different to polymers and behave differently in HME. This article highlights two glyceride-esters: Compritol® 888 ATO and Precirol® ATO 5. They melt at relatively low temperatures and recrystallize quickly. They extrude well and can produce strand-like extrudates which can be down streamed into powders or granules. 

 

These glyceride-esters can be used as release retarding agents/dissolution modifiers for both insoluble and soluble drugs even for high drug loading. In combination with plastic polymers they also can act as plasticizer/processing aid enabling lower temperature process and continuous production. 

 

At Gattefossé we aim to share our knowledge to help formulators use lipid excipients to their best advantage. 

Hot melt extrusion with Compritol® 888 ATO: determination of processing boundaries

  • Poster

PBP World Meeting – Vienna (Austria)  - Mar 2014

Yvonne Cuppok-Rosiaux, Florence Desvignes, Jean-Michel Girard, Cédric Miolane, Delphine Marchaud

Lipid matrix by hot melt extrusion: a practical industrial solution for solid dispersion

  • Poster

AAPS Annual Meeting & Exposition – Chicago (USA)  - Nov 2012

Yvonne CUPPOK, Jean-Michel GIRARD, Helena SCHREINER, Simon SCHNABEL, Albrecht HUBER, Delphine MARCHAUD

Preparation of hot melt extruded supersaturating solid dispersions containing glyceryl behenate: effects of processability, supersaturation and rate of release

  • Poster

AAPS Annual Meeting & Exposition – Washington DC (USA)  - Nov 2011

Justin M. Keen, Justin R. Hughey, Ryan C. Bennett, Vincent Jannin and James W. McGinity