All publications
In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations
ECP - Mar 2025
In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.
Understanding Microemulsions and Nanoemulsions in (Trans)Dermal Delivery
AAPS PharmSciTech - Jan 2025
Microemulsions and nanoemulsions are explored in pharmaceuticals for their potential in delivering clinically relevant drug doses across biological membranes. Despite extensive literature, there's a lack of clear distinctions between the two in terms of definitions and mechanisms: this review aims to uncover less obvious yet important mechanisms in transdermal drug delivery.
Bigels: case studies of an innovative topical dosage form
ABCF Congress - Nov 2024
Adherence to treatments is a key challenge for topical formulations. Bigels, formulated with Emulfree® Duo are an innovative dosage form that can combine both hydrophilic and lipophilic active ingredients in a stable, moisturizing, and easily spreadable formulation. This study showcases three different placebo bigels formulations.
Rheology as a tool for characterizing topical product formulations: impact of solubilizer variation on stability and structure
CRS - Jul 2024
The use of solubilizers in a topical formulation helps solubilization of poorly soluble APIs. Therefore, it is essential to have a formulation chassis that can be modulated to incorporate this quantity of solubilizer. In this poster, the influence of different excipients as solubilizers and their variation on the stability and rheological properties of topical creams is investigated.
Formulating pharmaceutical topical dosage forms with high level of solvents and minimal quantity of water
PBP - Mar 2024
This poster dives into the formulation of topical dosage forms containing the maximum amount of solvent and the minimum amount of water, while ensuring their stability upon storage.