All publications
Process analytical strategies for size monitoring: offline, at-line, online, and inline methods in a top-down nano-manufacturing line
Pharmaceutics - May 2025
This study highlights that combining offline, at-line, in-line, and online DLS methods enables thorough monitoring across the entire lipid nanoparticles production process. This integrated approach streamlines operations, supports real-time process adjustments, and ensures dependable quality control both post-production and during storage.
Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line considering critical measurement and process conditions
PBP - Mar 2024
Nanopharmaceuticals' size is a critical quality attribute. This work provides insights about the implementation of an at-line particle size analyzer in a continuous manufacturing line of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC).
Establishment of a continuous inline-monitored nano-production line using the Microfluidizer® technology for the fabrication of safe lipid-based nanoparticles
Macedonian Pharmaceutical Bulletin - Sep 2023
Nano-drug delivery systems (NDDS) serve as a promising platform in modern medicine, facilitating the targeted delivery of drugs due to their versatile size, structure, and composition. However, the current industrial production of NDDS relies on cumbersome batch processes that are costly, difficult to scale, and lack adequate control. This study focuses on enhancing industrial-scale production through the development and testing of a continuous top-down production line, utilizing scalable Microfluidizer® technology for solvent-free preparation of lipid-based nanoparticles.
The Gelucire® family
Pharma Excipients - 2018