All publications
In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations
ECP - Mar 2025
In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.
Understanding Microemulsions and Nanoemulsions in (Trans)Dermal Delivery
AAPS PharmSciTech - Jan 2025
Microemulsions and nanoemulsions are explored in pharmaceuticals for their potential in delivering clinically relevant drug doses across biological membranes. Despite extensive literature, there's a lack of clear distinctions between the two in terms of definitions and mechanisms: this review aims to uncover less obvious yet important mechanisms in transdermal drug delivery.
Effect of Select Enhancers on the Permeation of Caffeine Across Strat® M Membrane
CRS Annual Meeting – Montreal (Canada) - Jul 2022
Importance of standardizing protocols for pig skin preparation to ensure reliable in vitro permeation test (IVPT) results
CRS Annual Meeting – Montreal (Canada) - Jul 2022
Critical Criteria for Assessing the Permeation Performance of Topical Formulas on Animal Skin: Standardization of IVPT Protocols
PBP World Meeting – Rotterdam (The Netherlands) - Mar 2022
To assess the performance of dermal/transdermal formulation, in vitro permeation test (IVPT) with Franz cells is a reliable, reproducible, and widely used technique1. Due to its histological similarity, pig skin is a common model used as an alternative to human skin2. However, careful consideration should be given to the pig skin preparation, as both permeability and lag time can be greatly affected. The main variation sources are pig skin storage time, skin integrity and thickness, sample quantity and methodology to apply the formulation on the membrane. This study aims to investigate the critical parameters affecting the data’s accuracy by evaluating the permeation of a lidocaine hydrochloride-based gel (LID HCl) on pig skin.
Synergising excipients to boost skin delivery. A case study with lidocaine hydrochloride
Skinforum 2019 Annual Meeting – Reims (France) - Sep 2019
In this study, the authors showed that combining an efficient solubilizer and penetration enhancer achieves a synergic effect which enhances the passive diffusion of LID HCl through the Strat-M membrane in this Franz cell model.
A snapshot of lipid excipients for topical formulations
Pharma Times – Vol. 51 – No. 59 - Sep 2019
Lipid excipients in pharmaceutical technologies
Nabil FARAH and Joel DENIS
Lipidic excipients in drug delivery for solubility and bioavailability enhancement
Prashantkumar K. PARMAR, Srilaxmi G. RAO, Arvind KK. BANSAL
From exploration of lipids to its exploitation in market: Pharmaceuticals, Nutraceuticals and Herbal
Saurabh ARORA, Abhinav GARG, Karishma KAPOOR
A snapshot of lipid excipients for topical formulations
Renuka TIWARI, Ketkee DESHMUKH, Agnivesh SHRIVASTAVA, Kanchan KOHLI
Strategic lipid-based delivery interventions for enhancing oral bioavailability of BCS II/IV drugs
Teenu SHARMA, Ranjot KAUR, Sumant SAINI, Atul JAIN, Bhupinder SINGH
Unleashing role of excipients in overcoming formulation challenges
Meenakshi VENKATARAMAN, Megha MARWAH, Mangal NAGARSENKER
Role of lipid excipients in oral sustained release drug delivery systems
Divya JAIN, Namita DESAI
Synergising excipients to boost skin delivery
ONdrugDelivery Magazine, Issue 99, pp 54-58. - Aug 2019
This article focuses on Transcutol® P, Capryol® and Lauroglycol™ as their synergism brings eye-opening benefits in topical formulations.
Investigation of the permeation enhancer strategy on benzoylaconitine transdermal patch: the relationship between transdermal enhancement strength and physicochemical properties of permeation enhancer
Eur J Pharm Sci. 2019 Oct 1;138:105009. doi: 10.1016/j.ejps.2019.105009. Epub 2019 Jul 12. - Jul 2019
In this study several permeation enhancers are evaluated for their ability to permeate high molecular weight benzoylaconitine. The results showed that Plurol® Oleique CC 497 enabled the highest permeation. FT-IR studies demonstrated that the enhancer had strong interactions with the Stratum corneum, both in the hydrophilic and lipophilic regions. The optimized patch formulation showed excellent analgesic and antiinflammatory effect.