All publications
Formulation Components' Role in Shaping Continuous Nanocarrier Production through Impingement Jet Mixing
PBP - Mar 2024
Flash nanoemulsification with impingement jet mixing is a technique used to produce nanocarriers. This study optimized the nanocarrier formulation to facilitate the manufacturing process and monitoring.
Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line considering critical measurement and process conditions
PBP - Mar 2024
Nanopharmaceuticals' size is a critical quality attribute. This work provides insights about the implementation of an at-line particle size analyzer in a continuous manufacturing line of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC).
Establishment of a continuous inline-monitored nano-production line using the Microfluidizer® technology for the fabrication of safe lipid-based nanoparticles
Macedonian Pharmaceutical Bulletin - Sep 2023
Nano-drug delivery systems (NDDS) serve as a promising platform in modern medicine, facilitating the targeted delivery of drugs due to their versatile size, structure, and composition. However, the current industrial production of NDDS relies on cumbersome batch processes that are costly, difficult to scale, and lack adequate control. This study focuses on enhancing industrial-scale production through the development and testing of a continuous top-down production line, utilizing scalable Microfluidizer® technology for solvent-free preparation of lipid-based nanoparticles.
In vivo confirmation of the permeation enhancement capacity of Labrafac™ MC60
AAPS PharmSci360 – Orlando (USA) - Oct 2023
Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of insulin glargine
International Journal of Pharmaceutics 639 - 122964 - May 2023
In this study, lipophilicity of insulin glargine (IG) was successfully increased via hydrophobic ion pairing (HIP) with sodium octadecyl sulfate to enable incorporation into self-emulsifying drug delivery systems (SEDDS). The SEDDS formulations F1 and F2 were administered to rats via oral gavage and resulted in a bioavailability of 0.55% and 0.44%, corresponding to a 7.7-fold and 6.2-fold increased bioavailability, respectively. Thus, incorporation of complexed insulin glargine into SEDDS formulations provides a promising approach to facilitate its oral absorption.
LIPID-BASED EXCIPIENTS – Misconceptions About Lipid-Based Drug Delivery
Drug Development & Delivery - Apr 2023
An All-Purpose Vehicle for Low-Energy Capsule Filling
Tablets&Capsules - Apr 2023
Capsules are perceived as elegant, easy-to-swallow dosage forms, widely used for delivery of nutraceutical and medicinal preparations. Advances in capsule technologies have hugely facilitated the incorporation of liquid, semi-solid, and solid ingredients into capsules.
A Systematic Approach to Developing Lipid-Based Drug Delivery Systems with Fenofibrate as Model Drug
AAPS PharmSci360 – Boston (USA) - Oct 2022
Impact of Granulation Solvent on Release Performance of Dual Matrix Extended-Release Tablets of Highly Water Soluble Drugs Formulated using Compritol® 888 ATO and Methocel® as Release Retarding Agents
AAPS PharmSci360 – Boston (USA) - Oct 2022
The purpose of this study is to evaluate the impact of different granulation solvents on the performance of dual extended- release matrix tablets, formulated using a combination of Compritol® 888 ATO and Methocel® K100M, with two model APIs:
- highly water-soluble high dose (1000 mg) Metformin Hydrochloride
- freely water-soluble low dose (95 mg) Metoprolol Succinate