Nos publications
Skin Penetration and Permeation Properties of Transcutol® in Complex Formulations
AAPS PharmSciTech - sep 2024
The review examines how hydroalcoholic solvents, especially Transcutol, enhance drug delivery in multi-component formulations. It highlights factors like drug diffusion, solubilization, and skin absorption, focusing on the interaction between drug properties, skin barrier, and formulation for effective (trans)dermal delivery.
Rheology as a tool for characterizing topical product formulations: impact of solubilizer variation on stability and structure
CRS - jui 2024
The use of solubilizers in a topical formulation helps solubilization of poorly soluble APIs. Therefore, it is essential to have a formulation chassis that can be modulated to incorporate this quantity of solubilizer. In this poster, the influence of different excipients as solubilizers and their variation on the stability and rheological properties of topical creams is investigated.
Comparing the effect of adding Gelucire® 48/16 and Gelucire® 50/13 in amorphous solid dispersion: a case study with ticagrelor
CRS - jui 2024
When amorphous solid dispersion (ASD) are produced by hot melt extrusion (HME), the use of a neat polymer requires high process temperatures, and the drug release is not always complete. Adding Gelucire® in the formula is a promising strategy to address these issues.
Labrafac™ MC60 is an efficacious intestinal permeation enhancer for macromolecules: Comparisons with Labrasol® ALF in ex vivo and in vivo rat studies
International Journal of Pharmaceutics - jui 2024
In this article, demonstration on how Labrafac™ MC60 acts as a safe intestinal permeation enhancer is given, with insulin as a model molecule. Studies were conducted in vivo and ex vivo, using isolated muscle-stripped rat jejunal and colonic mucosae.
The Role of Lipids in Mitigation of Food Effect
American Pharmaceutical Review - mar 2024
In this paper, after a general description of the effect of food on gastrointestinal physiology, drugs, and formulation, the role of lipids is explained along with their digestion and absorption mechanisms. Case studies with self-emulsifying drug delivery systems (SEDDS) are presented as a way to mitigate the food effect. Current in vitro methods to determine indicators for the food effect during the drug development stage are also described.
Formulating pharmaceutical topical dosage forms with high level of solvents and minimal quantity of water
PBP - mar 2024
This poster dives into the formulation of topical dosage forms containing the maximum amount of solvent and the minimum amount of water, while ensuring their stability upon storage.
Advantages of combining polymers and lipids in extrusion processes
PBP - mar 2024
Lipid excipients lower the glass transition temperature of polymers, enabling hot-melt extrusion at lower engine torque for better processability. Different polymers and lipid combinations have been tested to explore their potential in extrusion processes.
Precision Engineering of Lipid-Based Nanosystems via Impingement Jet Mixing
PBP - mar 2024
Formulation Components' Role in Shaping Continuous Nanocarrier Production through Impingement Jet Mixing
PBP - mar 2024
Flash nanoemulsification with impingement jet mixing is a technique used to produce nanocarriers. This study optimized the nanocarrier formulation to facilitate the manufacturing process and monitoring.