Bi-gel, opening up innovation potential
Bi-gels consist of an intimate mixture of an aqueous gel and an oily gel. Due to their dual nature, bi-gels are associated with the following advantages: suitable for lipophilic and hydrophilic drugs, better drug absorption through the skin, cooling and moisturizing effects and improved spreadability.
Mixing intimately aqueous and oily gels
Bi-gels are usually produced by preparing separately the aqueous gel and the oily gel, and then mixing both phases at high speed. Depending on the gelling agents used in both phases, different ratios water/oil phases can be achieved, and process temperature and mixing speed need to be adapted.
Discover the process in video
Bi-gels made easy with Emulfree® Duo
Emulfree® duo is an oil-stabilizing agent, processable at room temperature and a PEG-free excipient.