An oily vehicle and solubilizer of lipophilic APIs for oral and topical lipid-based formulations (LBFs).
Names & synonyms
| USP NF Name | Medium chain triglycerides |
|---|---|
| EP Name | Triglycerides medium chain |
| UNII Code (FDA) | C9H2L21V7U |
| Preferred Substance Name (FDA) | MEDIUM-CHAIN TRIGLYCERIDES |
| Handbook of Pharmaceutical Excipients | MEDIUM-CHAIN TRIGLYCERIDES |
| Chemical description | Consists of medium-chain triglycerides of caprylic (C8) and capric (C10) acids |
Key characteristics
| Product form | Liquid |
|---|---|
| Viscosity (mPa.s) | 25 - 33 (20°C) |
| HLB | 1 |
Main functionalities
Oily vehicle in LFCS Type I, Type II (SEDDS), and Type III formulations (SMEDDS). Oil phase for topical formulations. Oily vehicle and solubilizer for solutions. Safety of use is inferred by food additive status and precedence of use in approved pharmaceutical products.
Main formulation technologies
Oily and self-emulsifying lipid formulation for oral applications. Topical ointment, emulsion, microemulsion, and foam. Oily vehicle for injectable veterinary drugs.
Resources
Technical documentation
Brochures
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Gattefosse brochure Selecting the best excipients to optimize drug delivery
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Gattefosse brochure Lipid excipients for cannabinoid drug products
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Gattefosse brochure Oral drug delivery with lipid excipients
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Gattefosse Brochure Skin-Friendly Textures
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Gattefosse brochure veterinary medicines with Lipid excipients
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Brochure Gattefosse Lipid-based formulations Bio-enhancers by nature
Scientific document
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Poster AAPS 2014: Establishment of a Binary Phase Diagrams Database for the Development of Self Emulsifying Lipid Based Formulations
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Poster PBP 2024 - Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line considering critical measurement and process conditions
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Poster PBP 2024 - Precision Engineering of Lipid-Based Nanosystems via Impingement Jet Mixing
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Poster PBP 2024 - Formulation Components' Role in Shaping Continuous Nanocarrier Production through Impingement Jet Mixing
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Poster PBP 2024 - Formulating pharmaceutical topical dosage forms with high level of solvents and minimal quantity of water
Associated content
Excipients for solubility and bioavailability enhancement
Poor solubility, poor permeability, and pre-systemic elimination are factors that…