Hard fat suppository base with modified monoglyceride content providing hydrophilic properties. Confers high mechanical resistance and yields harder suppository or pessary units.

Names & synonyms


Hard fat

EP Name

Hard fat



Preferred Substance Name (FDA)

Fat, hard

Handbook of Pharmaceutical Excipients

Suppository bases, hard fat

Chemical description

Consists of mono-, di- and triglyceride esters of fatty acids (C10 to C18), the triester fraction being predominant

Key characteristics

Product form


Melting range (°C)

33.5 - 35.5

Hydroxyl value (mg KOH/g)

40 - 50

suppocire nas 50 thermorheogram

Main functionnalities

Base recrystallizes rapidly and produces harder suppository units with high mechanical resistance. Used as pessary base for numerous APIs.

Main formulation technologies

Suppository molding.

Associated content

Hard fats for suppositories

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Alternative dosage forms for rectal and vaginal drug delivery

  • Formulation technologies

If solid dosage units, i.e. suppositories and pessaries, are very frequent for…