Hard fats for suppositories

At Gattefossé, we know how important the selection of the suppository base is, and we have developed guidelines to help select the right base depending on the drug properties:  

• Drug physical form: solid, liquid, waxy 
• Drug load 
• Drug solubility in hard fat 
• Homogeneity of drug dispersion 
• Risk of drug exudation 

Our bases and formulation expertise enable to: 

• simplify existing formulations by reducing the number of excipients 
• optimize the manufacturing process and reduce quality issues 
• obtain excellent product quality attributes including drug dissolution, i.e., efficacy 

Watch our video to understand how Gattefossé can help shorten your suppository development

Our hard fat bases have proven safety and mucosal tolerance, excellent drug dispersion and physicochemical stability, narrow melting range for high performance in vivo and solidification behavior adapted for a wide range of manufacturing equipment. Focus on some bases in our range.

Suppocire® AM and Suppocire® NAI 25 A  are multipurpose vehicles, suitable for a wide spectrum of APIs. They are ideal for straightforward formulations using manual, semi-automated, or fully automated equipment.

Some APIs are more difficult to formulate due to properties such as hydrophilicity, sensitivity to oxidation, or high drug load. They require special bases like the following: