Hard fat suppository base with high crystallization rate, incorporating phospholipids to facilitate high drug loading.

Names & synonyms

USP NF Name

Hard fat with additive (lecithin)

EP Name

Hard fat with additive

UNII Code (FDA)

Not applicable

Preferred Substance Name (FDA)

Fat, hard

Handbook of Pharmaceutical Excipients

Suppository bases, hard fat

Chemical description

Consists of mono-, di- and triglyceride esters of fatty acids (C10 to C18), the triester fraction being predominant and containing lecithin

Key characteristics

Product form

Pellets

Melting range (°C)

34 - 38

Hydroxyl value (mg KOH/g)

<10

suppocire aml thermorheogram

Main functionnalities

Facilitates dispersion of large concentrations of APIs. Recrystallizes rapidly.

Main formulation technologies

Suppository molding.

Associated content

Hard fats for suppositories

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Alternative dosage forms for rectal and vaginal drug delivery

  • Formulation technologies

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