Hard fat suppository base that provides excellent chemical stability with acidic APIs and high crystallization rate. A versatile base with precedence of use with a wide range of APIs.

Names & synonyms


Hard fat

EP Name

Hard fat



Preferred Substance Name (FDA)

Fat, hard

Handbook of Pharmaceutical Excipients

Suppository bases, hard fat

Chemical description

Consists of mono-, di- and triglyceride esters of fatty acids (C10 to C18), the triester fraction being predominant

Key characteristics

Product form


Melting range (°C)

34 - 36

Hydroxyl value (mg KOH/g)


suppocire am thermorheogram

Main functionalities

Versatile base for straightforward formulations recommended for acidic APIs.

Main formulation technologies

Suppository molding.

Associated content

Hard fats for suppositories

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Alternative dosage forms for rectal and vaginal drug delivery

  • Formulation technologies

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