A solid co-emulsifier in topical formulations to improve stability of emulsions. Can be used in rectal and vagina alternative dosage forms (cream).
Names & synonyms
| USP NF Name | Lauroyl polyoxyl-6 glycerides |
|---|---|
| EP Name | Lauroyl macrogol-6 glycerides |
| UNII Code (FDA) | 8EPU9MJ01K |
| Preferred Substance Name (FDA) | HYDROGENATED PALM/PALM KERNEL OIL PEG-6 ESTERS |
| Handbook of Pharmaceutical Excipients | Polyoxylglycerides |
| Chemical description | Consists mainly of mono-, di- and triglycerides and PEG-6 (MW 300) mono- and diesters of lauric (C12) and stearic (C18) acids |
Key characteristics
| Product form | Waxy solid |
|---|---|
| Melting point (°C) | 33 - 38 |
| HLB | 9 |
Main functionalities
Co-emulsifier in topical formulations often associated with Tefose® 1500. APIs solubilizer as co-surfactant.
Safety of use is inferred by substantial toxicological data and precedence of use in approved pharmaceutical products.
Main formulation technologies
Topical cream and lotion.
Resources
Technical documentation
Brochures
Scientific document
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Poster AAPS 2016: Converting simple microemulsion into attractive foam for topical treatment case study with Lidocaine
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Poster AAPS 2018_A systematic approach to formulate and evaluate the stability of topical creams with high concentrations of Transcutol® HP
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Poster Skin Formulation 2023 - Advanced rheological characterization of topical products
Associated content
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