A solid co-emulsifier in oral and topical formulations to improve stability of emulsions. Can be used in rectal and vaginal alternative dosage forms (cream).
Names & synonyms
| USP NF Name | Lauroyl polyoxyl-6 glycerides |
|---|---|
| EP Name | Lauroyl macrogol-6 glycerides |
| UNII Code (FDA) | 8EPU9MJ01K |
| Preferred Substance Name (FDA) | HYDROGENATED PALM/PALM KERNEL OIL PEG-6 ESTERS |
| Handbook of Pharmaceutical Excipients | Polyoxylglycerides |
| Chemical description | Consists mainly of mono-, di- and triglycerides and PEG-6 (MW 300) mono- and diesters of lauric (C12) and stearic (C18) acids |
Key characteristics
| Product form | Waxy solid |
|---|---|
| Melting point (°C) | 33 - 38 |
| HLB (PIT method) | 9 ± 1 |
Main functionalities
Co-emulsifier in topical formulations often associated with Tefose® 1500. APIs solubilizer as co-surfactant, for oral dosage forms.
Safety of use is inferred by substantial toxicological data and precedence of use in approved pharmaceutical products.
Main formulation technologies
Oral tablets and capsules.
Topical cream and lotion.
Resources
Technical documentation
Brochures
Scientific document
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Poster AAPS 2016: Converting simple microemulsion into attractive foam for topical treatment case study with Lidocaine
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Poster AAPS 2018_A systematic approach to formulate and evaluate the stability of topical creams with high concentrations of Transcutol® HP
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Poster Skin Formulation 2023 - Advanced rheological characterization of topical products
Associated content
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