Guardian of DNA

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A physical barrier between the inside and the outside, the skin is one of the most responsive organs to external aggressions, particularly to UV radiation. This latter strongly impacts the heart of skin cells, the DNA, leading to structural and functional alterations of the different skin layers.

Solastemis™ acts at the heart of the epidermis mechanics, by protecting the DNA of keratinocytes from UVA rays and boosting endogenous DNA repair system. It preserves the stem cells of the epidermis ensuring proper homeostasis for the skin’s first line of defense. It also offers a shield for the dermis by protecting key matrix proteins (collagen, elastin) from degradation.

Photoaging associated symptoms are visibly corrected: wrinkles are reduced, the microrelief is smoothed, the skin complexion appears brighter, more even and healthier.


  • Protects the skin from UVA-induced DNA lesions
  • Preserves epidermal stem cells
  • Shields the skin from photo-aging
  • Smoothes the skin and visibly reduces wrinkles
  • Improves skin tone homogeneity
  • Provides a healthy lucent complexion
  • Use level

  • COSMOS approved
    Natural origin (ISO 16128): 99.8%

  • Fructose (and) Glycerin (and) Water (and) Sechium Edule Fruit Extract

    China NMPA notified

The ingredient video summary

Mechanism of action

In-vitro test results on collagen I solastemis

Several in vitro models have been combined to demonstrate the ability of SOLASTEMISTM to :

  • Protect and repair DNA from lesions induced by UVA exposure
  • Maintain the self-renewal potential of keratinocytes, also called stemness
  • Provide a global photoprotection at dermal and epidermal level

Discover more about the science behind Solastemis™ with Gattefossé's R&D director

Clinical evaluation

wrinkles in vivo picture Solastemis

A double-blind clinical trial (active versus placebo) confirmed SolastemisTMefficacy on various symptoms of photoaging.

It efficiently reduces crow’s feet wrinkles and improves skin smoothness. Skin tone is embellished for a more lucent, glowing and even complexion. 


Solastemis™ is derived from chayote (Sechium edule), a fruit cultivated and manually harvested on Reunion Island (French oversea territory), in the majestic Cirque of Salazie.

The extraction with a NaDES solvent makes an eco-designed and fully natural ingredient (99.85% content of natural origin according to ISO16128) associated with high biological performances.

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