A liquid nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a coarse dispersion, i.e., emulsion (SEDDS).
Names & synonyms
| USP NF Name | Linoleoyl Polyoxyl-6 glycerides |
|---|---|
| EP Name | Linoleoyl Macrogol-6 glycerides |
| UNII Code (FDA) | 1U4409FY0P |
| Preferred Substance Name (FDA) | CORN OIL PEG-6 ESTERS |
| Handbook of Pharmaceutical Excipients | Polyoxylglycerides |
| Chemical description | Consists of mono-, di- and triglycerides and PEG-6 (MW 300) mono- and diesters of linoleic (C18:2) acid |
Key characteristics
| Product form | Liquid |
|---|---|
| Viscosity (mPa.s) | 70 - 90 (20°C) |
| HLB | 9 |
Main functionalities
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion—LFCS Type II (SEDDS). Combine with Labrasol® ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS). Co-emulsifier in topical formulations. Safety of use is inferred by substantial toxicological data and precedence of use in approved pharmaceutical products.
Main formulation technologies
Resources
Technical documentation
Associated content
Excipients for solubility and bioavailability enhancement
Poor solubility, poor permeability, and pre-systemic elimination are factors that…