A non-ionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a fine dispersion, i.e., microemulsion (SMEDDS).
Names & synonyms
|USP NF Name||
Mixture of Lauroyl Polyoxyl-32 glycerides and PEG 6000
Mixture of Lauroyl Macrogol-32 glycerides and PEG 6000
|UNII Code (FDA)||
|Preferred Substance Name (FDA)||
LAUROYL PEG-32 GLYCERIDES
POLYETHYLENE GLYCOL 6000
|Handbook of Pharmaceutical Excipients||
Consists of a small fraction of mono, di- and triglycerides and mainly PEG-32 (MW 1500) mono- and diesters of lauric acid (C12) and of PEG-150 (MW 6000)
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into microemulsion—LFCS Type III (SMEDDS). Safety of use is inferred by extensive toxicological evaluations and precedence of use in approved pharmaceutical products.
Main formulation technologies
Self-emulsifying lipid formulation for oral applications.