All publications
In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations
ECP - Mar 2025
In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.
Effect of Select Enhancers on the Permeation of Caffeine Across Strat® M Membrane
CRS Annual Meeting – Montreal (Canada) - Jul 2022
Importance of standardizing protocols for pig skin preparation to ensure reliable in vitro permeation test (IVPT) results
CRS Annual Meeting – Montreal (Canada) - Jul 2022
Critical Criteria for Assessing the Permeation Performance of Topical Formulas on Animal Skin: Standardization of IVPT Protocols
PBP World Meeting – Rotterdam (The Netherlands) - Mar 2022
To assess the performance of dermal/transdermal formulation, in vitro permeation test (IVPT) with Franz cells is a reliable, reproducible, and widely used technique1. Due to its histological similarity, pig skin is a common model used as an alternative to human skin2. However, careful consideration should be given to the pig skin preparation, as both permeability and lag time can be greatly affected. The main variation sources are pig skin storage time, skin integrity and thickness, sample quantity and methodology to apply the formulation on the membrane. This study aims to investigate the critical parameters affecting the data’s accuracy by evaluating the permeation of a lidocaine hydrochloride-based gel (LID HCl) on pig skin.
Synergising excipients to boost skin delivery. A case study with lidocaine hydrochloride
Skinforum 2019 Annual Meeting – Reims (France) - Sep 2019
In this study, the authors showed that combining an efficient solubilizer and penetration enhancer achieves a synergic effect which enhances the passive diffusion of LID HCl through the Strat-M membrane in this Franz cell model.
A systematic approach to formulate and evaluate the stability of topical creams with high concentrations of Transcutol® HP
AAPS PharmSci 360 – Washington DC (USA) - Nov 2018
In this study the authors developped stable anhydrous and hydrous creams containing 40% Transcutol® HP, using predictive techniques to select appropriate excipients.
Designing aqueous gels with lipophilic solubilizers for dermal application
AAPS Annual Meeting and Exposition – San Diego (USA) - Nov 2014
Measuring solubility performance of skin penetration enhancers for three anti-inflammatory drugs
PBP World Meeting – Vienna (Austria) - Mar 2014