All publications

Formulation Components' Role in Shaping Continuous Nanocarrier Production through Impingement Jet Mixing

  • Poster

PBP - Mar 2024

C. Tetyczka, M. Zettl, C. Glader, R. Jeitler, S. Stephan, M. Segl, Y. Wang, P. Caisse, V. Bourgeaux, M. Spoerk, J. Khinast, E. Roblegg

Flash nanoemulsification with impingement jet mixing is a technique used to produce nanocarriers. This study optimized the nanocarrier formulation to facilitate the manufacturing process and monitoring.

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Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line considering critical measurement and process conditions

  • Poster

PBP - Mar 2024

C. Glader, R. Jeitler, N. Cacic, Y. Wang, C. Tetyczka, M. Zettl, J. Khinast, M. Rossano, S. Mesite, M. Lübbert, E. Roblegg

Nanopharmaceuticals' size is a critical quality attribute. This work provides insights about the implementation of an at-line particle size analyzer in a continuous manufacturing line of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC).

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Precision Engineering of Lipid-Based Nanosystems via Impingement Jet Mixing

  • Poster

PBP - Mar 2024

M. Zettl, C. Tetyczka, C. Glader, R. Jeitler, S. Stephan, M. Segl, Y. Wang, P. Caisse, V. Bourgeaux, M. Spoerk, E. Roblegg, J. Khinast

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Establishment of a continuous inline-monitored nano-production line using the Microfluidizer® technology for the fabrication of safe lipid-based nanoparticles

  • Scientific publication

Macedonian Pharmaceutical Bulletin - Sep 2023

Christina Glader, Ramona Jeitler, Yan Wang, Carolin Tetyczka, Manuel Zettl, Johannes Khinast, Manon Rossano, Steve Mesite, Matthias Lübbert, Eva Roblegg

Nano-drug delivery systems (NDDS) serve as a promising platform in modern medicine, facilitating the targeted delivery of drugs due to their versatile size, structure, and composition. However, the current industrial production of NDDS relies on cumbersome batch processes that are costly, difficult to scale, and lack adequate control. This study focuses on enhancing industrial-scale production through the development and testing of a continuous top-down production line, utilizing scalable Microfluidizer® technology for solvent-free preparation of lipid-based nanoparticles.