Oxi-inflammation unmasked
What if your skin, this essential barrier that protects us from the outside world, was threatened by two invisible enemies? Oxidative inflammation, or oxi-inflammation, a harmful combination of oxidative stress and inflammation, has emerged as one of the main mechanisms responsible for many skin disorders. This article delves into the root causes of oxi-inflammation, its specific manifestations on the skin, and why it is crucial to protect against it.
Oxi-inflammation: silent action
The skin is the most exposed of all the organs in the body, making it highly susceptible to environmental stressors. These stressors include pollution, UV rays, and certain lifestyle choices, collectively known as the “exposome.” One of the primary consequences of skin exposure to these external stress factors is the activation of two interconnected biological pathways: the overproduction of free radicals or ROS (Reactive Oxygen Species) and high inflammation levels, whose interplay has recently been termed “oxi-inflammation”.
At the origin, there is an imbalance. Eexogenous factors disrupt the skin’s delicate balance by triggering the overproduction of oxidative molecules, such as ROS. The generation of various oxidation degradation products acts as secondary toxic messengers that activate signaling pathways linked to inflammation. This subsequent inflammation is, in turn, a significant source of oxidative stress. This self-sustaining cycle fosters a pro-oxi-inflammatory environment that is particularly harmful to skin tissue
The role of epidermal lipids
Epidermal lipids are particularly prone to this phenomenon. They are essential components for a functional and robust epidermis, forming a protective cocoon. In the stratum corneum, intercellular lipids maintain the barrier function. In the living epidermis, lipids surround the keratinocytes membranes, regulating the movement of substances in and out of cells.
Lipid oxidation, also known as lipoperoxidation, produces a wide variety of oxidation products, some of which are highly reactive and directly activate inflammatory pathways and the synthesis of pro-inflammatory cytokines. Lipoperoxidation can thus be considered a significant pathway for oxi-inflammatory reactions. Thus, the skin becomes vulnerable, and struggles to regenerate, resulting in a compromised barrier function.
Sensitive skin: a manifestation of oxi-inflammation
The development of conditions such as excessive reactivity, diffuse redness, and persistent discomfort is the direct result of this phenomenon.
The skin becomes prone to sensitivity, particularly noticeable on the most exposed parts, such as the face.
Tingling, burning sensations, and discomfort are frequent signs of a weakened skin barrier, and are amplified by environmental factors.
New solution coming soon…
Gattefossé laboratories developed a new bioactive to address this issue. Rich in antioxidant and anti-inflammatory polyphenols, it tackles the phenomenon of oxi-inflammation in every direction. More specifically, it calms the oxi-inflammatory environment generated by the oxidation of epidermal lipids and features impressive soothing effects.
Stay tuned to learn more...