Understanding Skin Aging: Insights from the 18th Symposium of the French Society of Cosmetology
This Tuesday, December 10, Chloé Lorion, engineer & coordinator of R&D projects in cellular biology, spoke at the 18th Symposium of the French Society of Cosmetology on the theme of skin aging.
Skin aging is a dynamic and cumulative process resulting from biological alterations, exacerbated by extrinsic factors. During aging, the first harmful effects on the skin are caused by the production of free radicals that induce an inflammatory cascade. Reconstituted skin is the most relevant in vitro model to simulate the complexity of the process and age-related changes. It is in this context that our laboratory transposed in vitro the phenomenon of epidermal lipid oxidation, in order to develop a screening tool for our various candidate cosmetic active ingredients.
A complex mixture of artificial lipids representative of those naturally present in the stratum corneum was developed, then deliberately subjected to an oxidation protocol, modeling an aggressive exposome, representative of our urban lives. This oxidized lipid mix is then applied to a 3D model of reconstructed epidermis.
To find out which candidate best protects the skin to resist these recurring attacks, check back in the coming months for more information!