Gattefossé and Ambiotis have explored the role of pro-resolving lipids in skin aging

Long considered a natural result of time and external aggressions, skin aging is now understood to stem from a deeper, silent imbalance; one that weakens the skin and undermines its natural ability to defend and regenerate itself. This imbalance leads to visible signs such as wrinkles, loss of firmness, and tissue sagging.
While the clinical signs of aged skin are now well documented, the molecular and cellular dysregulations involved mean that skin aging remains a largely misunderstood process.
To maintain healthy, vital skin and promote healthy aging, cosmetic solutions primarily target the synthesis of dermal extracellular matrix proteins, such as collagen and elastin.
Embracing new, more integrative approaches – capable of better reflecting the skin’s biological complexity – will open the door to the next-generation of anti-aging solutions.

It is within this context that Gattefossé and Ambiotis have combined their scientific expertise to study the role of pro-resolving lipids found in the secretome, in interaction with macrophages – true sentinels of the immune system – and fibroblasts, the key architectural cells of the dermal extracellular matrix.

Gattefossé and Ambiotis have thus characterized and modeled the alterations of pro-resolving lipids observed in aged skin, revealing that these changes disrupt the interactions between macrophages and dermal fibroblasts. As a result, dermal fibroblasts become abnormally activated, adopting a pro-inflammatory and pro-degradative phenotype marked by increased secretion of matrix metalloproteinases.

This joint research conducted by Gattefossé and Ambiotis aims to design and develop innovative cosmetic solutions to combat skin aging.