Lauroglycol™ 90

A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.

Names and synonyms

USP NF Name

Propylene glycol monolaurate (type II)

EP Name

Propylene glycol monolaurate (type II)

UNII Code (FDA)

40KT317HGP

Preferred Substance Name (FDA)

PROPYLENE GLYCOL LAURATES

Handbook of Pharmaceutical Excipients

Propylene glycol monolaurate

Chemical description

Consists of propylene glycol mono- and di- esters of lauric (C12) acid, mainly composed of monoesters and a small fraction of diesters

Key characteristics

Product form

Liquid

Viscosity (mPa.s)

25 (20°C)

HLB

3

Main functionalities

Solubilizer for poorly-soluble APIs and bioavailability enhancer.
Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations.
Solubilizer and cosurfactant for microemulsion in topical formulation.
Safety of use is inferred by precedence of use in approved pharmaceutical products.

Main formulation technologies