All publications
Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating
International Journal of Pharmaceutics, Volume 538, Issues 1–2, Pages 159-166 - Mar 2018
The aim of this study was to evaluate the mucus permeating properties of self-emulsifying drug delivery systems (SEDDS). Small droplet size and negative zeta potential of SEDDS could be identified as key parameters for their mucus permeating properties.
Size characterization of lipid-based self-emulsifying pharmaceutical excipients during lipolysis using Taylor dispersion analysis with fluorescence detection
International Journal of Pharmaceutics, Volume 537, Issues 1–2, Pages 94–101 - Feb 2018
In this work, the lipolysis of Labrasol® and Gelucire® 44/14 , two lipid based self-emulsifying drug delivery systems, by pancreatic enzymes and under conditions mimicking the gastrointestinal tract is followed by Taylor dispersion analysis. Results show that, Labrasol® droplets decrease exponentially in size with lipolysis time, whereas Gelucire® 44/14 droplets increased sigmoïdally in size. Even after 120 min lipolysis, both systems maintain a solubilizing capacity of the hydrophobic marker.
Evaluation of the digestibility of solid lipid nanoparticles of glyceryl dibehenate produced by two techniques: Ultrasonication and spray-flash evaporation
European Journal of Pharmaceutical Sciences , Volume 111, Pages 91-95 https://doi.org/10.1016/j.ejps.2017.09.049 - Jan 2018
In this study, solid lipid nanoparticles (SLN) of glyceryl dibehenate are produced by two methods and evaluated for digestion using the in vitro lipolysis test.
By ultrasonication, SLN have a mean particle size of 180 nm and showed a limited digestion by lipase.
By spray-flash evaporation, SLN particle size ranges from 235 to 411 nm, depending on process conditions and were not digested by lipase.