All publications
LIPID-BASED DELIVERY – Are Lipid-Based Drug Delivery Systems in Your Formulation Toolbox?
Drug Development & Delivery, Vol. 17, No. 7, p.20-25 - Oct 2017
This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome impediments to good bioavailability of therapeutic actives, including poor water solubility, low permeability, and degradation by stomach acid or enzymes in vivo.
Amélioration de la biodisponibilité des substances actives via la formulation [Bioavailability enhancement of active pharmaceutical ingredients through formulation strategies] galénique
STP Pharma Pratiques, Mai-Juin 2017, n°1 - 2017
The SFSTP commission on Bioavailability published an article reviewing the formulation strategies to enhance the bioavailability of APIs.
Interestingly this article is both in French and English languages.
Table of content:
I Introduction
II Prerequisites
1 Initial identification and characterization of the active ingredient
1.1 Physico-chemical characteristics
1.2 Impact of physicochemical characteristics on absorption
1.3 Passive diffusion prediction tools
1.4 In silico prediction
2 Biopharmaceutical classifications
III Formulation strategies
1 Prerequisites
2 Techniques for increasing the dissolution rate
3 Solubility enhancement technologies
4 Improving the permeability, oral route
IV Control, assessment, prediction of the bioavailability
1 Physicochemical control methods for the manufacturing intermediates and finished products
2 Assessing and predicting the bioavailability of the formulations
V Alternative strategy: changing the route of administration
VI Conclusion: decision tree
