All publications
Advantages of combining cellulosic polymers and lipids in extruded 3D printing filaments - Part I
ECP - Mar 2025
This study explores the use of 3D printing, specifically fused deposition modeling (FDM), for personalized medicine by combining lipids and cellulosic excipients like hypromellose (HPMC). Hot-melt extrusion (HME) is employed to create filaments, with a focus on balancing processing temperatures and mechanical properties.
In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations
ECP - Mar 2025
In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.
Veterinary soft chews using Gelucire® 50/13 and Precirol® ATO 5. A proof of concept with wet extrusion
ECP - Mar 2025
This study aims to demonstrate the effectiveness of Gelucire® 50/13, a surfactant, and Precirol® ATO 5, a taste-masking agent, in producing veterinary soft chews using a wet extrusion process. These ingredients enable the development of high-drug load formulations with taste-masking capabilities and customizable drug release profiles, making them ideal for this innovative dosage form.