All publications
Continuous twin screw melt granulation of glyceryl behenate: Development of controlled release tramadol hydrochloride tablets for improved safety.
International Journal of Pharmaceutics, Volume 487, Issues 1–2, Pages 72-80 https://doi.org/10.1016/j.ijpharm.2015.03.058 - Jun 2015
The objective of this study was to develop a continuous granulation process for direct production of granules using this technique with glyceryl behenate as a binder, evaluate the properties of the resulting granules and develop controlled release tablets containing tramadol HCl.
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase
Pharmaceutical Research volume 32, pages 1279–1287 DOI: 10.1007/s11095-014-1532-y - Apr 2015
Biorelevant media resistant co-culture model mimicking permeability of human intestine.
International Journal of Pharmaceutics, Volume 481, Issues 1–2, Pages 27-36 - Mar 2015
Cell culture models are currently used to predict absorption pattern of new compounds and formulations in the human gastro-intestinal tract (GIT). One major drawback is the lack of relevant apical incubation fluids allowing mimicking luminal conditions in the GIT. Here, we suggest a culture model compatible with biorelevant media, namely Fasted State Simulated Intestinal Fluid (FaSSIF) and Fed State Simulated Intestinal Fluid (FeSSIF).
Optimizing a wet granulation process to obtain high-dose sustained-release tablets with Compritol® 888 ATO.
Drug Development and Industrial Pharmacy, Volume 41 - Issue 10 https://doi.org/10.3109/03639045.2014.1002410 - Feb 2015
This study demonstrates how a wet granulation with Compritol® 888 is an effective approach to improve material flow and compressibility. High-dose lipid matrix tablets with sustained release profiles were successfully produced.
Exploring the possible relationship between the drug release of Compritol®-containing tablets and its polymorph forms using micro X-ray diffraction
Journal of Controlled Release, Volume 197, Pages 158-164 https://doi.org/10.1016/j.jconrel.2014.11.013 - Jan 2015
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels.
The AAPS Journal, volume 16, pages 1344–1357 DOI: 10.1208/s12248-014-9672-x - Nov 2014
Effect of Tablet Structure on Controlled Release from Supersaturating Solid Dispersions Containing Glyceryl Behenate.
Mol. Pharmaceutics, 2015, 12 (1), pp 120–126 DOI: 10.1021/mp500480y - Oct 2014
Solid lipid excipients — Matrix agents for sustained drug delivery
Journal of Controlled Release Volume 188, Pages 18–30 - Aug 2014
This review article focuses on the utility of lipid excipients in solid sustained drug delivery systems with emphasis on the efficiency and robustness of these systems with respect to: (i) the choice of the manufacturing process and impact on drug release, (ii) the fundamental drug release mechanisms, (iii) resistance of the drug formulation under physiological conditions and (iv) long-term stability. Understanding the functionality of these versatile excipients in formulation is elementary for the development of highly robust lipid-based sustained release medicines
A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure
European Journal of Pharmaceutics and Biopharmaceutics, Volume 87, Issue 2, Pages 290-298 https://doi.org/10.1016/j.ejpb.2014.03.017 - Jul 2014