All publications
Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione
International Journal of Pharmaceutics, Volume 523, Issue 1, Pages 357–365 https://doi.org/10.1016/j.ijpharm.2017.03.027 - May 2017
This study shows that independent from the type of peptide all the SEDDS showed a prolonged release and can provide a 100% protective effect towards protease degradation and deactivation by reduced glutathione.
Hydrophobic ion pairing: Key to highly payloaded self-emulsifying peptide drug delivery systems
International Journal of Pharmaceutics, Volume 520, Issues 1–2, 30 March 2017, Pages 267–274 - Mar 2017
In this study, hydrophobic ion pairing is used to form complexes between different anionic surfactants and leuprorelin, insulin and desmopression as model peptides. These complexes were formulated in SEDDS and evaluated for payload and stability.
Comparative evaluation of Compritol® HD5 ATO with Sodium Stearyl Fumarate and PEG 6000 as amphiphilic, hydrodispersible pharmaceutical lubricants
Journal of Excipients and Food Chemicals, Vol. 8, Issue 1, pages 5-17 - Mar 2017
In the present study the lubricant capacity of Compritol® HD5 ATO was compared with commonly used amphiphilic lubricants. The
effect of the concentration and mixing time on flow properties, tablet ejection force, hardness, disintegration time and rate of dissolution of paracetamol tablets was evaluated.
The physical properties of the lubricants such as crystallinity, wettability, thermal behaviour and surface area were also measured.
Compritol® HD5 ATO was found to be an as effective a lubricant for a fast disintegrating paracetamol formulation containing microcrystalline cellulose, lactose and PVP prepared by wet granulation in comparison with sodium stearyl fumarate and PEG 6000.
In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates
International Journal of Pharmaceutics, Volume 515, Issues 1–2, Pages 293-299 https://doi.org/10.1016/j.ijpharm.2016.10.012 - Dec 2016
Hydrodynamic size characterization of a self-emulsifying lipid pharmaceutical excipient by Taylor dispersion analysis with fluorescent detection
International Journal of Pharmaceutics, Volume 513, Issues 1–2, Pages 262-269 - Nov 2016
In this study the size of microemulsion droplets is carried out using Tailor Dispersion Analysis in comparison to Dynamic Light Scattering. The size evolution of a Labrasol® self emulsifying drug delivery system as a function of concentration and temperature is evaluated. The influence of physical parameters and polydispersity is discussed.
Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity
International Journal of Pharmaceutics, Volume 495, Issue 1, Pages 385-392 - Nov 2015
This article describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcumin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.
Influence of Formulation Factors and Compression Force on Release Profile of Sustained Release Metoprolol Tablets using Compritol® 888 ATO as Lipid Excipient
Indian J Pharm Sci 2015;77(5): 620-625 - Sep 2015
Release profile of metoprolol from sustained release tablets using Compritol® 888 ATO as SR lipid matrix agent showed high reliability. Different sources of active ingredient and batches of Compritol® were evaluated at different compression forces and in dissolution media containing or not ethanol. The formulation appeared to be very robust and is not affected by these variables. Therefore Compritol® offers great potential in the formulation of reliable SR tablets.
Size characterization of commercial micelles and microemulsions by Taylor dispersion analysis
International Journal of Pharmaceutics, Volume 492, Issues 1–2, Pages 46-54 - Aug 2015
In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract.
Drug Development and Industrial Pharmacy - Volume 41 - Issue 10 https://doi.org/10.3109/03639045.2014.972412 - 2015