All publications
In-vitro evaluation of solid lipid nanoparticles: Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract
International Journal of Pharmaceutics, Volume 565, Pages 409-418 - Jun 2019
A Proof of Concept for 3D Printing of Solid Lipid-Based Formulations of Poorly Water-Soluble Drugs to Control Formulation Dispersion Kinetics
Pharmaceutical Research volume 36, Article number: 102 doi: 10.1007/s11095-019-2639-y. - May 2019
In this study, the authors show that solid SMEDDS can be produced with a 3D printing process and solid and semi-solid lipid excipients. The proof of concept is established with cinnarizine and fenofibrate as model drugs.
Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs
Advanced Drug Delivery Reviews, Volume 142, Pages 16-34 https://doi.org/10.1016/j.addr.2019.01.008 - May 2019
In this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.
A review of the techniques used to characterize the colloidal structures is also carried out.
An efficient method to determine the Hydrophile-Lipophile Balance of surfactants using the phase inversion temperature deviation of Ci Ej /n-octane/water emulsions.
International Journal of Cosmetic Science, 41, 99–108 doi: 10.1111/ics.12516 - Apr 2019
Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis
International Journal of Pharmaceutics, Volume 559, Pages 228-234 - Mar 2019
Lipids and polymers in pharmaceutical technology: Lifelong companions
International Journal of Pharmaceutics, Volume 558, 10 March 2019, Pages 128-142 - Mar 2019
This article reviews the uses of lipids and polymers in pharmaceutical applications, alone or in combination, with a main focus on oral administration.
These topics were discussed at the Journées galéniques de Saint-Rémy de Provence in 2018, the Scientific Meeting sponsored by Gattefossé Foundation
High shear blending with glyceryl distearate provides individually coated drug particles for effective taste masking
Journal of Drug Delivery Science and Technology, Volume 48, Pages 437-449 - Dec 2018
In this study the authors used:
– A design of experiment, to evaluate the effect of process parameters (blending speed, chopper speed and coating time) on drug particle size.
– Potassium chloride as model drug.
The study showed:
– Individual particle coating was achieved at 450 rpm with 20% glyceryl distearate (Precirol® ATO 5) at 48°C
– High shear coating is as efficient as fluid bed coating for taste masking
– A trained sensory panel confirmed the effectiveness of the process on taste masking
Skin Penetration and Permeation Properties of Transcutol®—Neat or Diluted Mixtures
AAPS PharmSciTech, Vol. 19, No.8 DOI: 10.1208/s12249-018-1196-8 - Nov 2018
In this critical article, the authors have reviewed numerous studies in order to elucidate the mechanism of action of the highly purified diethylene glycol monoethyl ether TRANSCUTOL® on skin penetration and permeation.
An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems
Pharmaceutical Research volume 36, Article number: 4 doi: 10.1007/s11095-018-2531-1. - Nov 2018
In this review article, the authors describe the various technologies used for 3D printing and their application in the pharmaceutical field.
The potential for lipids and the opportunities for lipid-based drug delivery systems are highlighted.