All publications
Effect of Lipid Vehicles on Solubility, Stability, and Topical Permeation of Delta 9 Tetrahydrocannabinol
AAPS PharmSciTech, 23:223 - Jul 2022
Lipid-based nanocarriers for oral delivery of peptides
OCL, Volume 29, 1 https://doi.org/10.1051/ocl/2021040 - Jan 2022
Carving out a Niche in Pharmaceutical Drug Delivery
Pharma Times – Vol. 53 – No. 12 - Dec 2021
A 3D-Printed Polymer–Lipid-Hybrid Tablet towards the Development of Bespoke SMEDDS Formulations
Pharmaceutics 2021, 13, 2107 https://doi.org/10.3390/pharmaceutics13122107 - Dec 2021
Solid lipid Nanocarriers diffuse effectively through mucus and enter intestinal cells – but where is my peptide?
International Journal of Pharmaceutics, Volume 586, 119581 https://doi.org/10.1016/j.ijpharm.2020.119581 - Aug 2020
This study aimed to evaluate the potential of Hydrophobic Ion Pairing combined with Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) to improve peptide transport across the intestinal border using Caco-2 cell monolayers (enterocyte-like model) and Caco-2/HT29-MTX co-cultured monolayers (mucin-secreting model).
This study showed that hydrophobic ion pairing enabled high encapsulation efficiency of peptide in SLN and NLC. The lipid-based nanocarriers were highly internalized by Caco-2 cell monolayers and were able to cross the mucus barrier (Caco-2/HT29-MTX cell model). However, the peptide intestinal transport was limited by an extensive release from the carriers.
A proof-of-concept for developing oral lipidized peptide Nanostructured Lipid Carrier formulations
Journal of Drug Delivery Science and Technology, Volume 54, 101394 https://doi.org/10.1016/j.jddst.2019.101394 - Dec 2019
A proof-of-concept for developing oral lipidized peptide Nanostructured Lipid Carrier formulations
Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies
Journal of Controlled Release, Volume 310, Pages 115-126 https://doi.org/10.1016/j.jconrel.2019.08.008 - Sep 2019
In this study Labrasol® ALFwas investigated as an intestinal permeation enhancer in isolated rat colonic mucosae in Ussing chamber and in rat in situ intestinal instillations.
Labrasol® ALF (4 and 8 mg/mL) enhanced the transport of the paracellular markers across colonic mucosae. The enhancement was non-damaging, transient, and molecular weight-dependent.
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
European Journal of Pharmaceutical Sciences, Volume 137, 104967, ISSN 0928-0987, https://doi.org/10.1016/j.ejps.2019.104967. - Sep 2019
In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:
Poorly water soluble drugs and the link between physico-chemical properties and solubility, lipophilicity and permeability
Technologies to increase solubility and dissolution rate: salt formation, amorphous solid dispersions, lipid-based formulations
How to avoid precipitation and create a concentration gradient to improve absorption
Methods for modelling the performance such as Molecular Dynamics Simulations
In vitro methods for solubility and dissolution assessments
Methods to explore the absorption in the GI tract: GI concentration-time profile, in vitro digestion, in vitro models coupling dissolution and permeation, mucus diffusion
Impact of molecularly dissolved drug versus apparently dissolved drug (ie in colloidal structure)
Investigation of the permeation enhancer strategy on benzoylaconitine transdermal patch: the relationship between transdermal enhancement strength and physicochemical properties of permeation enhancer
Eur J Pharm Sci. 2019 Oct 1;138:105009. doi: 10.1016/j.ejps.2019.105009. Epub 2019 Jul 12. - Jul 2019
In this study several permeation enhancers are evaluated for their ability to permeate high molecular weight benzoylaconitine. The results showed that Plurol® Oleique CC 497 enabled the highest permeation. FT-IR studies demonstrated that the enhancer had strong interactions with the Stratum corneum, both in the hydrophilic and lipophilic regions. The optimized patch formulation showed excellent analgesic and antiinflammatory effect.