All publications
Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity
International Journal of Pharmaceutics, Volume 495, Issue 1, Pages 385-392 - Nov 2015
This article describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcumin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.
Influence of Formulation Factors and Compression Force on Release Profile of Sustained Release Metoprolol Tablets using Compritol® 888 ATO as Lipid Excipient
Indian J Pharm Sci 2015;77(5): 620-625 - Sep 2015
Release profile of metoprolol from sustained release tablets using Compritol® 888 ATO as SR lipid matrix agent showed high reliability. Different sources of active ingredient and batches of Compritol® were evaluated at different compression forces and in dissolution media containing or not ethanol. The formulation appeared to be very robust and is not affected by these variables. Therefore Compritol® offers great potential in the formulation of reliable SR tablets.
Size characterization of commercial micelles and microemulsions by Taylor dispersion analysis
International Journal of Pharmaceutics, Volume 492, Issues 1–2, Pages 46-54 - Aug 2015
In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract.
Drug Development and Industrial Pharmacy - Volume 41 - Issue 10 https://doi.org/10.3109/03639045.2014.972412 - 2015
Continuous twin screw melt granulation of glyceryl behenate: Development of controlled release tramadol hydrochloride tablets for improved safety.
International Journal of Pharmaceutics, Volume 487, Issues 1–2, Pages 72-80 https://doi.org/10.1016/j.ijpharm.2015.03.058 - Jun 2015
The objective of this study was to develop a continuous granulation process for direct production of granules using this technique with glyceryl behenate as a binder, evaluate the properties of the resulting granules and develop controlled release tablets containing tramadol HCl.
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase
Pharmaceutical Research volume 32, pages 1279–1287 DOI: 10.1007/s11095-014-1532-y - Apr 2015
Biorelevant media resistant co-culture model mimicking permeability of human intestine.
International Journal of Pharmaceutics, Volume 481, Issues 1–2, Pages 27-36 - Mar 2015
Cell culture models are currently used to predict absorption pattern of new compounds and formulations in the human gastro-intestinal tract (GIT). One major drawback is the lack of relevant apical incubation fluids allowing mimicking luminal conditions in the GIT. Here, we suggest a culture model compatible with biorelevant media, namely Fasted State Simulated Intestinal Fluid (FaSSIF) and Fed State Simulated Intestinal Fluid (FeSSIF).
Optimizing a wet granulation process to obtain high-dose sustained-release tablets with Compritol® 888 ATO.
Drug Development and Industrial Pharmacy, Volume 41 - Issue 10 https://doi.org/10.3109/03639045.2014.1002410 - Feb 2015
This study demonstrates how a wet granulation with Compritol® 888 is an effective approach to improve material flow and compressibility. High-dose lipid matrix tablets with sustained release profiles were successfully produced.
Exploring the possible relationship between the drug release of Compritol®-containing tablets and its polymorph forms using micro X-ray diffraction
Journal of Controlled Release, Volume 197, Pages 158-164 https://doi.org/10.1016/j.jconrel.2014.11.013 - Jan 2015