All publications

Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies

• Scientific publication

Journal of Controlled Release, Volume 310, Pages 115-126 https://doi.org/10.1016/j.jconrel.2019.08.008 - Sep 2019

Fiona Mc Cartney, Vincent Jannin, Stéphanie Chevrier, Hakime Boulghobra, Delyan R. Hristov, Nicolas Ritter, Cédric Miolane, Yann Chavant, Frédéric Demarne, David J. Brayden

In this study Labrasol® ALFwas investigated as an intestinal permeation enhancer in isolated rat colonic mucosae in Ussing chamber and in rat in situ intestinal instillations.

Labrasol® ALF (4 and 8 mg/mL) enhanced the transport of the paracellular markers  across colonic mucosae. The enhancement was non-damaging, transient, and molecular weight-dependent.

Investigation of Labrasol® ALF as an intestinal permeation enhancer: Ussing chambers and intestinal instillations

• Poster

Poster presented at Keystone Symposia on Molecular and Cellular Biology – Delivering Therapeutics Across Biological Barriers (E1) - Dublin (Ireland)  - May 2019

Fiona McCartney, Vincent Jannin and David J. Brayden