All publications
Labrafac™ MC60 is an efficacious intestinal permeation enhancer for macromolecules: Comparisons with Labrasol® ALF in ex vivo and in vivo rat studies
International Journal of Pharmaceutics - Jun 2024
In this article, demonstration on how Labrafac™ MC60 acts as a safe intestinal permeation enhancer is given, with insulin as a model molecule. Studies were conducted in vivo and ex vivo, using isolated muscle-stripped rat jejunal and colonic mucosae.
Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies
Journal of Controlled Release, Volume 310, Pages 115-126 https://doi.org/10.1016/j.jconrel.2019.08.008 - Sep 2019
In this study Labrasol® ALFwas investigated as an intestinal permeation enhancer in isolated rat colonic mucosae in Ussing chamber and in rat in situ intestinal instillations.
Labrasol® ALF (4 and 8 mg/mL) enhanced the transport of the paracellular markers across colonic mucosae. The enhancement was non-damaging, transient, and molecular weight-dependent.