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Impact of hot and wet granulation techniques on Compritol® 888 ATO lipid matrices for extended release of highly water soluble high dose API
CRS Annual Meeting – Seattle (2016) - 2016
The poster describes the formulation of sustained release tablets with Metformin HCl (a well-known oral antihyperglycemic) using Compritol® 888 ATO as a sustained release agent. Different granulation techniques were evaluated to elucidate the impact of formulation and process on tablet properties and drug release. The objective was to determine a simple process that enables the production of ‘smaller’ tablets, using less excipients, whilst maintaining therapeutic drug dose and obtaining drug release which passes Pharmacopeial specifications.
High Drug Load Lipid Matrix Tablets Prepared by Wet Granulation: PART II – Process Parameters
AAPS Annual Meeting and Exposition - San Antonio (USA) - Nov 2013
High Drug Load Lipid Matrix Tablets Prepared by Wet Granulation: PART I – Formulation Parameters
AAPS Annual Meeting and Exposition - San Antonio (USA) - Nov 2013