All publications

Size characterization of lipid-based self-emulsifying pharmaceutical excipients during lipolysis using Taylor dispersion analysis with fluorescence detection

  • Scientific publication

International Journal of Pharmaceutics, Volume 537, Issues 1–2, Pages 94–101 - Feb 2018

Joseph Chamieh, Habib Merdassi, Jean-Christophe Rossi, Vincent Jannin, Frédéric Demarne, Hervé Cottet

In this work, the lipolysis of Labrasol® and Gelucire® 44/14 , two lipid based self-emulsifying drug delivery systems, by pancreatic enzymes and under conditions mimicking the gastrointestinal tract is followed by Taylor dispersion analysis. Results show that, Labrasol® droplets decrease exponentially in size with lipolysis time, whereas Gelucire® 44/14 droplets increased sigmoïdally in size. Even after 120 min lipolysis, both systems maintain a solubilizing capacity of the hydrophobic marker.

Hydrodynamic size characterization of a self-emulsifying lipid pharmaceutical excipient by Taylor dispersion analysis with fluorescent detection

  • Scientific publication

International Journal of Pharmaceutics, Volume 513, Issues 1–2, Pages 262-269 - Nov 2016

Vincent Jannin, Frédéric Demarne, Hervé Cottet

In this study the size of microemulsion droplets is carried out using Tailor Dispersion Analysis in comparison to Dynamic Light Scattering. The size evolution of a Labrasol® self emulsifying drug delivery system as a function of concentration and temperature is evaluated. The influence of physical parameters and polydispersity is discussed.

Size characterization of commercial micelles and microemulsions by Taylor dispersion analysis

  • Scientific publication

International Journal of Pharmaceutics, Volume 492, Issues 1–2, Pages 46-54 - Aug 2015

Joseph Chamieh, Florian Davanier, Vincent Jannin, Frédéric Demarne, Hervé Cottet

In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract.

  • Scientific publication

Drug Development and Industrial Pharmacy - Volume 41 - Issue 10 https://doi.org/10.3109/03639045.2014.972412 - 2015

Jannin V, Dellera E Chevrier S, Chavant Y, Voutsinas C, Bonferoni C, Demarne F.

Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase

  • Scientific publication

Pharmaceutical Research volume 32, pages 1279–1287 DOI: 10.1007/s11095-014-1532-y  - Apr 2015

Bakala-N’Goma, J.C., Williams, H.D., Sassene, P., Kleberg, K., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Müllertz, A., Pouton, C.W., Porter, C.J.H., Carrière, F.

Download (.pdf - 355.83 KB)

Biorelevant media resistant co-culture model mimicking permeability of human intestine.

  • Scientific publication

International Journal of Pharmaceutics, Volume 481, Issues 1–2, Pages 27-36 - Mar 2015

Delphine Antoine, Yann Pellequer, Camille Tempesta, Stefan Lorscheidt, Bernadette Kettel, Lana Tamaddon, Vincent Jannin, Frédéric Demarne, Alf Lamprecht, Arnaud Béduneau

Cell culture models are currently used to predict absorption pattern of new compounds and formulations in the human gastro-intestinal tract (GIT). One major drawback is the lack of relevant apical incubation fluids allowing mimicking luminal conditions in the GIT. Here, we suggest a culture model compatible with biorelevant media, namely Fasted State Simulated Intestinal Fluid (FaSSIF) and Fed State Simulated Intestinal Fluid (FeSSIF).

Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels.

  • Scientific publication

The AAPS Journal, volume 16, pages 1344–1357 DOI: 10.1208/s12248-014-9672-x - Nov 2014

Sassene, P.J., Kleberg, K., Williams, H.D., Bakala-N’Goma, J.C., Carrière, F., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Porter, C.J.H., Pouton, C.W., Müllertz, A.

A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure

  • Scientific publication

European Journal of Pharmaceutics and Biopharmaceutics, Volume 87, Issue 2, Pages 290-298 https://doi.org/10.1016/j.ejpb.2014.03.017 - Jul 2014

Arnaud Béduneau, Camille Tempesta, Stéphane Fimbel, Yann Pellequer, Vincent Jannin, Frédéric Demarne , Alf Lamprecht

In vitro lipolysis study of nanoparticulate delivery systems: solid lipid nanoparticles and nanostructured lipid carriers

  • Poster

AAPS Annual Meeting and Exposition – San Antonio (USA)  - Nov 2013

V. JANNIN, E. DELLERA, S. CHEVRIER, Y. CHAVANT, C. VOUTSINAS, C. BONFERONI, F. DEMARNE

Download (.pdf - 487.5 KB)