All publications
Process analytical strategies for size monitoring: offline, at-line, online, and inline methods in a top-down nano-manufacturing line
Pharmaceutics - May 2025
This study highlights that combining offline, at-line, in-line, and online DLS methods enables thorough monitoring across the entire lipid nanoparticles production process. This integrated approach streamlines operations, supports real-time process adjustments, and ensures dependable quality control both post-production and during storage.
In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations
ECP - Mar 2025
In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.
A QbD-based UPLC-ELSD method for quantifying medium-chain triglycerides in Labrafac™ WL 1349 for nanoemulsion applications
Molecules - Jan 2025
This article showcases the development and validation of a robust UPLC-ELSD method, using analytical Quality-by-Design principles, to accurately quantify medium-chain triglycerides in a lipid-based excipient for nanoemulsion applications, ensuring compliance with regulatory standards.