All publications
In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations
ECP - Mar 2025
In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.
Toward improving the in vitro in vivo correlation of lipid-based formulations using a simplified gastro-intestinal lipolysis protocol
AAPS - Oct 2024
Lipid-based formulations (LBF) enhance the oral bioavailability of poorly water-soluble drugs by maintaining them in a solubilized state during digestion. This study aims to establish a robust protocol to evaluate the impact of gastro-intestinal lipolysis on LBF performance, using cinnarizine as a model drug.
Rheology as a tool for characterizing topical product formulations: impact of solubilizer variation on stability and structure
CRS - Jul 2024
The use of solubilizers in a topical formulation helps solubilization of poorly soluble APIs. Therefore, it is essential to have a formulation chassis that can be modulated to incorporate this quantity of solubilizer. In this poster, the influence of different excipients as solubilizers and their variation on the stability and rheological properties of topical creams is investigated.
TAM Technique for Identifying API-Lipid Excipient Compatibility Issues Upstream in the Development Process
AAPS PharmSci 360 – Washington DC (USA) - Nov 2018
In this study the authors showed that Thermal Activity Monitoring is a useful technique to detect at early stage potential interaction between APi and excipients, using less time and resources than conventional techniques.
TAM technique is used routinely in Gattefossé North America Technical Center of Excellence to speed up formulation development.
In vitro lipolysis study of nanoparticulate delivery systems: solid lipid nanoparticles and nanostructured lipid carriers
AAPS Annual Meeting and Exposition – San Antonio (USA) - Nov 2013
Influence of intestinal biorelevant fluids on a novel co-culture cell model able to mimic varaible permeabilities of the human intestine
AAPS Annual Meeting and Exposition – San Antonio (USA) - 2013
In vitro lipolysis of the self-emulsifying excipient, Labrasol®
AAPS Annual Meeting & Exposition – San Diego (USA) - Nov 2007
The fate of some pharmaceutical surfactants during in vitro lipolysis and the effect on solubilization of a poorly soluble model compound
CRS Annual Meeting - 2006