All publications
Process analytical strategies for size monitoring: offline, at-line, online, and inline methods in a top-down nano-manufacturing line
Pharmaceutics - May 2025
This study highlights that combining offline, at-line, in-line, and online DLS methods enables thorough monitoring across the entire lipid nanoparticles production process. This integrated approach streamlines operations, supports real-time process adjustments, and ensures dependable quality control both post-production and during storage.
A QbD-based UPLC-ELSD method for quantifying medium-chain triglycerides in Labrafac™ WL 1349 for nanoemulsion applications
Molecules - Jan 2025
This article showcases the development and validation of a robust UPLC-ELSD method, using analytical Quality-by-Design principles, to accurately quantify medium-chain triglycerides in a lipid-based excipient for nanoemulsion applications, ensuring compliance with regulatory standards.
An efficient method to determine the Hydrophile-Lipophile Balance of surfactants using the phase inversion temperature deviation of Ci Ej /n-octane/water emulsions.
International Journal of Cosmetic Science, 41, 99–108 doi: 10.1111/ics.12516 - Apr 2019
Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis
International Journal of Pharmaceutics, Volume 559, Pages 228-234 - Mar 2019
Size characterization of lipid-based self-emulsifying pharmaceutical excipients during lipolysis using Taylor dispersion analysis with fluorescence detection
International Journal of Pharmaceutics, Volume 537, Issues 1–2, Pages 94–101 - Feb 2018
In this work, the lipolysis of Labrasol® and Gelucire® 44/14 , two lipid based self-emulsifying drug delivery systems, by pancreatic enzymes and under conditions mimicking the gastrointestinal tract is followed by Taylor dispersion analysis. Results show that, Labrasol® droplets decrease exponentially in size with lipolysis time, whereas Gelucire® 44/14 droplets increased sigmoïdally in size. Even after 120 min lipolysis, both systems maintain a solubilizing capacity of the hydrophobic marker.
Hydrodynamic size characterization of a self-emulsifying lipid pharmaceutical excipient by Taylor dispersion analysis with fluorescent detection
International Journal of Pharmaceutics, Volume 513, Issues 1–2, Pages 262-269 - Nov 2016
In this study the size of microemulsion droplets is carried out using Tailor Dispersion Analysis in comparison to Dynamic Light Scattering. The size evolution of a Labrasol® self emulsifying drug delivery system as a function of concentration and temperature is evaluated. The influence of physical parameters and polydispersity is discussed.
Size characterization of commercial micelles and microemulsions by Taylor dispersion analysis
International Journal of Pharmaceutics, Volume 492, Issues 1–2, Pages 46-54 - Aug 2015
In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract.
Drug Development and Industrial Pharmacy - Volume 41 - Issue 10 https://doi.org/10.3109/03639045.2014.972412 - 2015
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase
Pharmaceutical Research volume 32, pages 1279–1287 DOI: 10.1007/s11095-014-1532-y - Apr 2015