All publications

Impact of Granulation Solvent on Release Performance of Dual Matrix Extended-Release Tablets of Highly Water Soluble Drugs Formulated using Compritol® 888 ATO and Methocel® as Release Retarding Agents

  • Poster

AAPS PharmSci360 – Boston (USA)  - Oct 2022

Ketkee Deshmukh, Swarnadeep Banerjee, Agnivesh Shrivastava, Sunil Bambarkar

The purpose of this study is to evaluate the impact of different granulation solvents on the performance of dual extended- release matrix tablets, formulated using a combination of Compritol® 888 ATO and Methocel® K100M, with two model APIs:

- highly water-soluble high dose (1000 mg) Metformin Hydrochloride

- freely water-soluble low dose (95 mg) Metoprolol Succinate

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Exploring the Potential of Compritol® 888 ATO for Abuse Deterrent Sustained Release Tablets

  • Poster

CRS Annual Meeting – Montreal (Canada)  - Jul 2022

Agnivesh Shrivastava ; Renuka Tiwari ; Ketkee Deshmukh and Sunil Bambarkar

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Selecting efficient pharmaceutical binder for developing robust extended-release matrices of Compritol® 888 ATO prepared using wet granulation technique: Part 2 Studying impact on dissolution profiles of ER tablets of different API’s

  • Poster

CRS Annual Meeting - virtual  - Jul 2021

K. Deshmukh1, A. Shrivastava1, S. Banerjee1, R. Tiwari1, S. Bambarkar1, N. Farah2 1Gattefosse India Pvt. Ltd., Mumbai, INDIA, 2Gattefosse SAS, Lyon, FRANCE

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Selecting efficient pharmaceutical binder for developing robust extended-release matrices of Compritol® 888 ATO prepared using wet granulation technique: Part 1 Studying impact on granule & tablet properties

  • Poster

CRS Annual Meeting - virtual  - Jul 2021

K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah Gattefosse India Pvt. Ltd., Mumbai, INDIA, Gattefosse SAS, Lyon, FRANCE

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Selecting efficient pharmaceutical binder for developing robust extended-release matrices of Compritol® 888 ATO prepared using wet granulation technique: Part 1 Studying impact on granule & tablet properties

  • Poster

CRS Annual Meeting - virtual - Jul 2021

K. Deshmukh, A. Shrivastava, S. Banerjee, R. Tiwari, S. Bambarkar, N. Farah Gattefosse India Pvt. Ltd., Mumbai, INDIA, Gattefosse SAS, Lyon, FRANCE

QbD - How particle size and glyceride composition affect the performance of sustained-release tablets with Compritol 888 ATO

  • Poster

AAPS Annual Meeting & Exposition – San Diego (USA)  - Nov 2017

Yvonne Rosiaux, Amandine Forrest, Jean-Michel Girard, Carole Deleglise, Delphine Marchaud

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Compritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets

  • Poster

AAPS Annual Meeting & Exposition – Denver (USA) - Nov 2017

C. J. Kapadia, A. R. Shrivastava, G. R. Khanvilkar

Compritol® 888 ATO: a sustained release lipid matrix for once a day aceclofenac tablets

  • Poster

AAPS Annual Meeting & Exposition – Denver (USA)  - Nov 2016

C. J. Kapadia, A. R. Shrivastava, G. R. Khanvilkar

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Impact of hot and wet granulation techniques on Compritol® 888 ATO lipid matrices for extended release of highly water soluble high dose API

  • Poster

CRS Annual Meeting – Seattle (2016)  - 2016

Ketkee Deshmukh, Chhanda Kapadia, Agnivesh Shrivastava, Gayatri Khanvilkar, Pradnya Vaingankar and Purnima Amin

The poster describes the formulation of sustained release tablets with Metformin HCl (a well-known oral antihyperglycemic) using Compritol® 888 ATO as a sustained release agent. Different granulation techniques were evaluated to elucidate the impact of formulation and process on tablet properties and drug release. The objective was to determine a simple process that enables the production of ‘smaller’ tablets, using less excipients, whilst maintaining therapeutic drug dose and obtaining drug release which passes Pharmacopeial specifications. 

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