All publications
Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of insulin glargine
International Journal of Pharmaceutics 639 - 122964 - May 2023
In this study, lipophilicity of insulin glargine (IG) was successfully increased via hydrophobic ion pairing (HIP) with sodium octadecyl sulfate to enable incorporation into self-emulsifying drug delivery systems (SEDDS). The SEDDS formulations F1 and F2 were administered to rats via oral gavage and resulted in a bioavailability of 0.55% and 0.44%, corresponding to a 7.7-fold and 6.2-fold increased bioavailability, respectively. Thus, incorporation of complexed insulin glargine into SEDDS formulations provides a promising approach to facilitate its oral absorption.
Carving out a Niche in Pharmaceutical Drug Delivery
Pharma Times – Vol. 53 – No. 12 - Dec 2021
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
European Journal of Pharmaceutical Sciences, Volume 137, 104967, ISSN 0928-0987, https://doi.org/10.1016/j.ejps.2019.104967. - Sep 2019
In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:
Poorly water soluble drugs and the link between physico-chemical properties and solubility, lipophilicity and permeability
Technologies to increase solubility and dissolution rate: salt formation, amorphous solid dispersions, lipid-based formulations
How to avoid precipitation and create a concentration gradient to improve absorption
Methods for modelling the performance such as Molecular Dynamics Simulations
In vitro methods for solubility and dissolution assessments
Methods to explore the absorption in the GI tract: GI concentration-time profile, in vitro digestion, in vitro models coupling dissolution and permeation, mucus diffusion
Impact of molecularly dissolved drug versus apparently dissolved drug (ie in colloidal structure)
Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs
Advanced Drug Delivery Reviews, Volume 142, Pages 16-34 https://doi.org/10.1016/j.addr.2019.01.008 - May 2019
In this review article, the authors explain the importance of the colloidal structures formed during dispersion and digestion of self emulsifying lipid-based formulations on drug solubilization and absorption.
A review of the techniques used to characterize the colloidal structures is also carried out.
In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates
International Journal of Pharmaceutics, Volume 515, Issues 1–2, Pages 293-299 https://doi.org/10.1016/j.ijpharm.2016.10.012 - Dec 2016
Development of self emulsifying lipid formulations of BCS class II drugs with low to medium lipophilicity
International Journal of Pharmaceutics, Volume 495, Issue 1, Pages 385-392 - Nov 2015
This article describes the work undertaken in Gattefossé R&D labs (St Priest) to develop lipid formulations for low to medium lipophilicity API: piroxicam, nifedipine and curcumin and evaluate the effect of in-vitro digestion on the solubilizing capacity of the formulations.
Polyoxylglycerides and glycerides: Effects of manufacturing parameters on API stability, excipient functionality and processing
International Journal of Pharmaceutics, Volume 466, Issues 1–2, Pages 109-121 - May 2014