All publications
Size characterization of lipid-based self-emulsifying pharmaceutical excipients during lipolysis using Taylor dispersion analysis with fluorescence detection
International Journal of Pharmaceutics, Volume 537, Issues 1–2, Pages 94–101 - Feb 2018
In this work, the lipolysis of Labrasol® and Gelucire® 44/14 , two lipid based self-emulsifying drug delivery systems, by pancreatic enzymes and under conditions mimicking the gastrointestinal tract is followed by Taylor dispersion analysis. Results show that, Labrasol® droplets decrease exponentially in size with lipolysis time, whereas Gelucire® 44/14 droplets increased sigmoïdally in size. Even after 120 min lipolysis, both systems maintain a solubilizing capacity of the hydrophobic marker.
Hydrodynamic size characterization of a self-emulsifying lipid pharmaceutical excipient by Taylor dispersion analysis with fluorescent detection
International Journal of Pharmaceutics, Volume 513, Issues 1–2, Pages 262-269 - Nov 2016
In this study the size of microemulsion droplets is carried out using Tailor Dispersion Analysis in comparison to Dynamic Light Scattering. The size evolution of a Labrasol® self emulsifying drug delivery system as a function of concentration and temperature is evaluated. The influence of physical parameters and polydispersity is discussed.
In Vitro Digestion of the Self-Emulsifying Lipid Excipient Labrasol® by Gastrointestinal Lipases and Influence of its Colloidal Structure on Lipolysis Rate
Pharmaceutical Research volume 30, pages 3077–3087 DOI: 10.1007/s11095-013-1053-0 - May 2013
In vitro lipolysis of the self-emulsifying excipient, Labrasol®
AAPS Annual Meeting & Exposition – San Diego (USA) - Nov 2007