All publications

In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations

  • Poster

ECP - Mar 2025

Manon Rossano, Delphine Pélisson, Malaury Ducros, Elise Dauphin-Chanard, Philippe Caisse

In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.

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A QbD-based UPLC-ELSD method for quantifying medium-chain triglycerides in Labrafac™ WL 1349 for nanoemulsion applications

  • Scientific publication

Molecules - Jan 2025

Alessio Gaggero, Viktoria Marko, Dalibor Jeremic, Carolin Tetyczka, Philippe Caisse, Jesús Alberto Afonso Urich

This article showcases the development and validation of a robust UPLC-ELSD method, using analytical Quality-by-Design principles, to accurately quantify medium-chain triglycerides in a lipid-based excipient for nanoemulsion applications, ensuring compliance with regulatory standards.