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Establishment of a continuous inline-monitored nano-production line using the Microfluidizer® technology for the fabrication of safe lipid-based nanoparticles
Macedonian Pharmaceutical Bulletin - Sep 2023
Nano-drug delivery systems (NDDS) serve as a promising platform in modern medicine, facilitating the targeted delivery of drugs due to their versatile size, structure, and composition. However, the current industrial production of NDDS relies on cumbersome batch processes that are costly, difficult to scale, and lack adequate control. This study focuses on enhancing industrial-scale production through the development and testing of a continuous top-down production line, utilizing scalable Microfluidizer® technology for solvent-free preparation of lipid-based nanoparticles.