Nos publications

In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations

• Poster

ECP - mar 2025

Manon Rossano, Delphine Pélisson, Malaury Ducros, Elise Dauphin-Chanard, Philippe Caisse

In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.

Bigels: case studies of an innovative topical dosage form

• Poster

ABCF Congress - nov 2024

Delphine Pélisson, Manon Rossano, Paulo Cunha, Kelly Bueno, Philippe Caisse, Elise Dauphin-Chanard

Adherence to treatments is a key challenge for topical formulations. Bigels, formulated with Emulfree® Duo are an innovative dosage form that can combine both hydrophilic and lipophilic active ingredients in a stable, moisturizing, and easily spreadable formulation. This study showcases three different placebo bigels formulations.