Nos publications
In Vitro In Silico Correlation of Lidocaine HCl Skin Permeation - A Comparative Study of Gel Cream and Bigel formulations
ECP - mar 2025
In this work, the effectiveness of Skin-in-Silico™ software for simulating dermal absorption and permeation of lidocaine hydrochloride in gel, cream, and bi-gel forms was evaluated. By combining in silico predictions with in vitro experiments, we explore the correlation between these methods and their role in optimizing topical drug formulations.
Understanding Microemulsions and Nanoemulsions in (Trans)Dermal Delivery
AAPS PharmSciTech - jan 2025
Microemulsions and nanoemulsions are explored in pharmaceuticals for their potential in delivering clinically relevant drug doses across biological membranes. Despite extensive literature, there's a lack of clear distinctions between the two in terms of definitions and mechanisms: this review aims to uncover less obvious yet important mechanisms in transdermal drug delivery.
Synergising excipients to boost skin delivery
ONdrugDelivery Magazine, Issue 99, pp 54-58. - aou 2019
This article focuses on Transcutol® P, Capryol® and Lauroglycol™ as their synergism brings eye-opening benefits in topical formulations.
Self-formulation protocol: Part II: excipient selection, diagram design and selection of prototype formulations.
AAPS Annual Meeting and Exposition - San Antonio (USA) - nov 2013
Dispersion test and ternary diagramming are detailed, to determine the excipient ratios and prototype formulations
Self-formulation protocol: Part III: impact of lipolysis on prototype formulations
AAPS Annual Meeting and Exposition - San Antonio (USA) - 2013
Lipolysis test is used to determine the capacity of prototype formulations to maintain drug in solubilized state.
Self-formulation protocol: Part I: Solubility determination in liquid and solid excipients
AAPS Annual Meeting and Exposition – San Antonio (USA) - 2013
Dispersion test and ternary diagramming are detailed, to determine the excipient ratios and prototype formulations