Nos publications

Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line considering critical measurement and process conditions

  • Poster

PBP - mar 2024

C. Glader, R. Jeitler, N. Cacic, Y. Wang, C. Tetyczka, M. Zettl, J. Khinast, M. Rossano, S. Mesite, M. Lübbert, E. Roblegg

Nanopharmaceuticals' size is a critical quality attribute. This work provides insights about the implementation of an at-line particle size analyzer in a continuous manufacturing line of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC).

Formulation Components' Role in Shaping Continuous Nanocarrier Production through Impingement Jet Mixing

  • Poster

PBP - mar 2024

C. Tetyczka, M. Zettl, C. Glader, R. Jeitler, S. Stephan, M. Segl, Y. Wang, P. Caisse, V. Bourgeaux, M. Spoerk, J. Khinast, E. Roblegg

Flash nanoemulsification with impingement jet mixing is a technique used to produce nanocarriers. This study optimized the nanocarrier formulation to facilitate the manufacturing process and monitoring.

Precision Engineering of Lipid-Based Nanosystems via Impingement Jet Mixing

  • Poster

PBP - mar 2024

M. Zettl, C. Tetyczka, C. Glader, R. Jeitler, S. Stephan, M. Segl, Y. Wang, P. Caisse, V. Bourgeaux, M. Spoerk, E. Roblegg, J. Khinast

Advantages of combining polymers and lipids in extrusion processes

  • Poster

PBP - mar 2024

Ceren Yüce, Lolie Cheron, Anja Geissler-Fichtner, Elsa Gattefossé

Lipid excipients lower the glass transition temperature of polymers, enabling hot-melt extrusion at lower engine torque for better processability. Different polymers and lipid combinations have been tested to explore their potential in extrusion processes.

Formulating pharmaceutical topical dosage forms with high level of solvents and minimal quantity of water

  • Poster

PBP - mar 2024

Delphine Pélisson, Elise Dauphin-Chanard

This poster dives into the formulation of topical dosage forms containing the maximum amount of solvent and the minimum amount of water, while ensuring their stability upon storage.

In vivo confirmation of the permeation enhancement capacity of Labrafac™ MC60

  • Poster

AAPS PharmSci360 – Orlando (USA) - oct 2023

Fiona McCartney, Philippe Caisse , Camille Dumont, David J. Brayden

Impact of Granulation Solvent on Release Performance of Dual Matrix Extended-Release Tablets of Highly Water Soluble Drugs Formulated using Compritol® 888 ATO and Methocel® as Release Retarding Agents

  • Poster

AAPS PharmSci360 – Boston (USA)  - oct 2022

Ketkee Deshmukh, Swarnadeep Banerjee, Agnivesh Shrivastava, Sunil Bambarkar

The purpose of this study is to evaluate the impact of different granulation solvents on the performance of dual extended- release matrix tablets, formulated using a combination of Compritol® 888 ATO and Methocel® K100M, with two model APIs:

- highly water-soluble high dose (1000 mg) Metformin Hydrochloride

- freely water-soluble low dose (95 mg) Metoprolol Succinate

A Systematic Approach to Developing Lipid-Based Drug Delivery Systems with Fenofibrate as Model Drug

  • Poster

AAPS PharmSci360 – Boston (USA)  - oct 2022

Masumi Dave, Reena Rahi and Jasmine Musakhanian

Labrafac™ MC60 acts as an intestinal permeation enhancer in isolated rat colonic and jejunal mucosae in the Ussing chambers

  • Poster

CRS Annual Meeting – Montreal (Canada)  - jui 2022

Fiona McCartney ; Camille Dumont ; Philippe Caisse and David J. Brayden