A nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.
Names & synonyms
|USP NF Name||
|UNII Code (FDA)||
|Preferred Substance Name (FDA)||
|Handbook of Pharmaceutical Excipients||
Consists of polyglyceryl-3 esters of oelic acid (C18:1), the diester fraction being predominant.
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Co-surfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations.
Solubilizer and Solubilizer and skin penetration enhancer. Co-surfactant for microemulsion in topical formulations.
Safety of use is inferred by precedence of use in approved pharmaceutical products.