A nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a coarse dispersion, i.e., emulsion (SEDDS). Co-emulsifier in topical formulations to improve stability of emulsions.
Names & synonyms
|USP NF Name||
Oleoyl polyoxyl-6 glycerides
Oleoyl macrogol-6 glycerides
|UNII Code (FDA)||
|Preferred Substance Name (FDA)||
APRICOT KERNEL OIL PEG-6 ESTERS
|Handbook of Pharmaceutical Excipients||
Consists of mono-, di- and triglycerides and PEG-6 (MW 300) mono- and diesters of oleic (C18:1) acid
Solubilizer for poorly-soluble API and bioavailability enhancer Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion – LFCS type II (SEDDS) Combine with Labrasol®ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS) Co-emulsifier in topical formulations often associated with Tefose® 63 in antifungal cream Safety of use is supported by substantial toxicological data and precedence of use in approved pharmaceutical products.
Main formulation technologies
Self-emulsifying lipid formulation for oral applications Soft/hard gelatin capsule filling and vials Topical and mucosal cream, emulgel, microemulsion and foam. Oily vehicle for injectable veterinary drugs.